Conditional survival and long-term efficacy with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma.
Robert J MotzerDavid F McDermottBernard EscudierMauricio BurottoToni K ChoueiriHans J HammersPhilippe BarthélémyElizabeth R PlimackCamillo PortaSaby GeorgeThomas PowlesFrede DonskovHoward GurneyChristian K KollmannsbergerMarc-Oliver GrimmCarlos BarriosYoshihiko TomitaDaniel CastellanoViktor GrünwaldBrian I RiniM Brent McHenryChung-Wei LeeJennifer McCarthyFlavia EjzykowiczNizar M TannirPublished in: Cancer (2022)
Durable clinical benefits were observed with NIVO+IPI versus SUN at 5 years, the longest phase 3 follow-up for a first-line checkpoint inhibitor-based combination in patients with aRCC. Conditional estimates indicate that most patients who remained alive or in response with NIVO+IPI at 3 years remained so at 5 years.