Last-step 18 F-fluorination of supported 2-(aryl-di- tert -butylsilyl)- N -methyl-imidazole conjugates for applications in positron emission tomography.
Marine SteffannMarion TisseraudGuillaume BluetSebastien RoyCatherine AubertEric FouquetPhilippe HermangePublished in: Chemical communications (Cambridge, England) (2022)
Aiming for potential applications in positron emission tomography, fully automated productions of 18 F-labelled bioconjugates were achieved using heterogenous precursors obtained by anchoring imidazole-di- tert -butyl-arylsilanes to a polystyrene resin. The reactions were performed using either "batch" or "flow" procedures, avoiding both the time-consuming azeotropic drying and HPLC purifications usually required.
Keyphrases
- positron emission tomography
- computed tomography
- ms ms
- biofilm formation
- pet ct
- pet imaging
- simultaneous determination
- machine learning
- high throughput
- deep learning
- high performance liquid chromatography
- solid phase extraction
- cancer therapy
- tandem mass spectrometry
- escherichia coli
- candida albicans
- climate change
- single cell
- drug delivery
- liquid chromatography