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Carbapenem-Susceptible OXA-23-Producing Proteus mirabilis in the French Community.

Anais PotronDidier HocquetPauline TriponneyPatrick PlésiatXavier BertrandBenoit Valot
Published in: Antimicrobial agents and chemotherapy (2019)
Nineteen Proteus mirabilis isolates producing the carbapenemase OXA-23 were recovered over a 2-year period in 19 French hospitalized patients, of whom 12 had community onset infections. The isolates exhibited a slightly reduced susceptibility to carbapenems. Whole-genome analysis revealed that all 19 isolates formed a cluster compared to 149 other P. mirabilis isolates. Because of its susceptibility to carbapenems, this clone may be misidentified as a penicillinase producer while it constitutes a reservoir of the OXA-23-encoding gene in the community.
Keyphrases
  • klebsiella pneumoniae
  • acinetobacter baumannii
  • multidrug resistant
  • drug resistant
  • genetic diversity
  • mental health
  • healthcare
  • pseudomonas aeruginosa
  • escherichia coli
  • genome wide
  • gene expression
  • single cell