Perioperative Circulating Tumor DNA in Colorectal Liver Metastases: Concordance with Metastatic Tissue and Predictive Value for Tumor Burden and Prognosis.

Yiping HeXiaoji MaKe ChenFangqi LiuSanjun CaiHan Han-ZhangTing HouJianxing XiangJunjie Peng

Published in: Cancer management and research (2020)

Our data demonstrate that the genomic profile obtained from ctDNA is comparable with the genomic profile obtained from metastatic liver tumors. Furthermore, our study also show that pre-surgery ctDNA levels are positively correlated with tumor burden. In addition, pre-surgery ctDNA, cfDNA and CEA levels have predictive value for relapse.

Keyphrases

circulating tumor
liver metastases
minimally invasive
cell free
circulating tumor cells
coronary artery bypass
squamous cell carcinoma
small cell lung cancer
copy number
cardiac surgery
electronic health record
big data
gene expression
acute kidney injury
acute coronary syndrome