Concentrations and pharmacokinetic parameters of MRI and SPECT hepatobiliary agents in rat liver compartments.

Catherine M PastorFlorian JolyValérie VilgrainPhilippe Millet

Published in: European radiology experimental (2021)

Hepatocyte concentrations are correlated to liver extraction ratios of hepatobiliary agents. When Bopta is not present in canaliculi of cholestatic livers, hepatocyte concentrations increase in comparison to normal livers. This new understanding extends the interpretation of clinical liver images.

Keyphrases

liver injury
magnetic resonance imaging
drug induced
deep learning
oxidative stress
computed tomography
optical coherence tomography