Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma.

Michael HemingSvea HaessnerJolien WolbertI-Na LuXiaolin LiBenjamin BrokinkelMichael MütherMarkus HollingWalter StummerChristian ThomasAndreas Schulte-MecklenbeckFlavia de FariaMarlon StoeckiusStephan HailfingerGeorg LenzKornelius KerlHeinz Wiendl Gerd Meyer Zu Hörste Oliver M Grauer

Published in: Genome medicine (2022)

Malignant B cells in PCNSL show transcriptional and spatial intratumor heterogeneity. T cell exhaustion is frequent in the PCNSL microenvironment, co-localizes with malignant cells, and highlights the potential of personalized treatments.

Keyphrases

single cell
induced apoptosis
cell cycle arrest
stem cells
gene expression
diffuse large b cell lymphoma
transcription factor
oxidative stress
heat shock
cell proliferation
heat stress