TLR4/NF-κB/TNFα and cAMP/SIRT1 signaling cascade involved in mediating the dose-dependent effect of cilostazol in ovarian ischemia reperfusion-induced injury.
Marwa Monier Mahmoud RefaieMaram El-HussienySayed ShehataPublished in: Immunopharmacology and immunotoxicology (2022)
CLZ could ameliorate OIR-induced damage due to PDE inhibition, anti-oxidant, anti-inflammatory and anti-apoptotic properties with modulation of TLR4/NF-κB/TNFα and cAMP/SIRT1 signaling pathways.
Keyphrases
- oxidative stress
- signaling pathway
- anti inflammatory
- diabetic rats
- nuclear factor
- high glucose
- toll like receptor
- rheumatoid arthritis
- inflammatory response
- pi k akt
- lps induced
- immune response
- cell death
- ischemia reperfusion injury
- drug induced
- binding protein
- cell proliferation
- endothelial cells
- induced apoptosis
- protein kinase
- endoplasmic reticulum stress