HIGD2A silencing impairs hepatocellular carcinoma growth via inhibiting mitochondrial function and the MAPK/ERK pathway.

Kuiyuan HuangZiying LiuZhanglian XieXiaoran LiHaixing ZhangYu ChenYiran WangZimo LinChuanjiang LiHongyan LiuXiaoyong Zhang

Published in: Journal of translational medicine (2023)

HIGD2A promoted liver cancer cell growth by fueling mitochondrial ATP synthesis and activating the MAPK/ERK pathway, suggested that targeting HIGD2A may represent a new strategy for HCC therapy.

Keyphrases

signaling pathway
pi k akt
oxidative stress
cell proliferation