Compensatory post-diuretic renal sodium reabsorption is not a dominant mechanism of diuretic resistance in acute heart failure.
Zachary L CoxVeena S RaoJuan Betuel Ivey-MirandaJulieta Moreno-VillagómezDevin MahoneyPiotr PonikowskiJan BiegusJeffrey M TurnerChristopher MaulionLavanya BellumkondaJennifer L AsherHelen PariseFrancis Perry WilsonDavid H EllisonChristopher S WilcoxJeffrey M TestaniPublished in: European heart journal (2021)
On a population level, CPDSR was not an important driver of diuretic resistance in hypervolemic ADHF. Contrary to CPDSR, a greater diuretic-induced natriuresis predicted a larger post-diuretic spontaneous natriuresis. Basal sodium avidity, rather than diuretic-induced CPDSR, appears to be the predominant determinate of both diuretic-induced and post-diuretic natriuresis in hypervolemic ADHF.