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Palladium-Catalyzed Defluorinative Alkylation of gem -Difluoroalkenes with Cyclopropanols: Stereoselective Synthesis of γ-Fluorinated γ,δ-Unsaturated Ketones.

Lingyu KongWenqing TiAijun LinHequan YaoYue HuangXuanyi Li
Published in: Organic letters (2024)
A palladium-catalyzed defluorinative alkylation of gem -difluoroalkenes with cyclopropyl alcohols was developed. A range of γ-fluorinated γ,δ-unsaturated ketones were constructed in good yields with excellent stereoselectivities. In addition, by base-mediated intramolecular nucleophilic vinylic substitution (S N V), the products could be further transformed to 2,5-dimethylenetetrahydrofurans and analogues with excellent stereoselectivities.
Keyphrases
  • wastewater treatment
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  • energy transfer
  • structure activity relationship