Cerebrovascular reactivity in cerebral amyloid angiopathy, Alzheimer disease, and mild cognitive impairment.
Aaron R SwitzerIkreet CheemaCheryl R McCrearyAngela ZwiersAnna CharltonAna Alvarez-VeronesiRamnik SekhonCharlotte ZernaRandall B StaffordRichard FrayneBradley G GoodyearEric E SmithPublished in: Neurology (2020)
Mean visual BOLD response amplitude was lowest in participants with CAA compared to controls, without differences in VEP latencies and amplitudes. This suggests that the impaired visual BOLD response is due to reduced vascular reactivity in CAA. In contrast to participants with CAA, the visual BOLD response amplitude did not differ between those with AD or MCI and controls.