Multifactorial effects matter: Moving thermal adaptation into a real-world setting.

We often study climate change impact by isolating various drivers and manipulating them at ideal state, despite that in reality those drivers change independent of each other and may produce unexpected results due to possible complex interacting effects over time. Even though global change experiments that examine multiple interacting global change factors are becoming more common, few have been applied to studies on thermal compensatory response of microbial respiration. We propose future studies on thermal adaptation to include multifactorial experiments.