Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling.

Eleonora SementinoYuwaraj KadariyaMitchell CheungCraig W MengesYinfei TanAnna-Mariya KukuyanUjjawal ShresthaSofiia KarchuginaKathy Q CaiSuraj PeriJames S DuncanJonathan Chernoff Joseph R Testa

Published in: Molecular cancer research : MCR (2022)

We provide evidence supporting a role for PAK inhibitors in treating NF2-deficient tumors. NF2-deficient tumors lacking Pak2 eventually adapt by kinome reprogramming, presenting opportunities for combination therapies to bypass anti-PAK drug resistance.

Keyphrases

signaling pathway
lps induced
pi k akt
nuclear factor
oxidative stress
wild type
case report
cell proliferation