GW9508 ameliorates cognitive dysfunction via autophagy pathway in streptozotocin-induced mouse model of Alzheimer's disease.
Yanan WangJingjing ChenChen WangTong ChenLing HePublished in: Fundamental & clinical pharmacology (2024)
Peripheral administration of GW9508 exhibits neuroprotective effects, and it could be a promising therapy for AD. The neuroprotective mechanism of GW9508 was based on promoting gut-brain peptide secretion, activating Akt/mTOR signal pathway, and regulating neuronal autophagy.
Keyphrases
- signaling pathway
- mouse model
- diabetic rats
- oxidative stress
- cerebral ischemia
- cell death
- endoplasmic reticulum stress
- cell proliferation
- cognitive decline
- type diabetes
- white matter
- resting state
- adipose tissue
- metabolic syndrome
- blood brain barrier
- diabetic nephropathy
- drug induced
- brain injury
- endothelial cells
- insulin resistance