Time to Peak Glucose and Peak C-Peptide During the Progression to Type 1 Diabetes in the Diabetes Prevention Trial and TrialNet Cohorts.
Michael G VossDavid D CuthbertsonMario M ClevesPing XuCarmella Evans-MolinaJerry P PalmerMaria J RedondoAndrea K SteckMarkus LundgrenHelena LarssonWayne V MooreMark A AtkinsonJay M SosenkoHeba M Ismailnull nullPublished in: Diabetes care (2021)
In two independent at-risk populations, we show that those with delayed OGTT peak times for glucose or C-peptide are at higher risk of diabetes development within 5 years, independent of peak levels. Moreover, time to peak C-peptide appears more predictive than the peak level, suggesting its potential use as a specific biomarker for diabetes progression.