LRG1 Promotes Diabetic Kidney Disease Progression by Enhancing TGF-β-Induced Angiogenesis.

Quan HongLu ZhangJia FuDivya A VergheseKinsuk ChauhanGirish N NadkarniZhengzhe LiWenjun JuMatthias KretzlerGuang-Yan CaiXiang-Mei ChenVivette D D'AgatiSteven G CocaDetlef SchlondorffJohn C HeKyung Lee

Published in: Journal of the American Society of Nephrology : JASN (2019)

These findings identify LRG1 as a potential novel pathogenic mediator of diabetic glomerular neoangiogenesis and a risk factor in DKD progression.

Keyphrases

wound healing
high glucose
endothelial cells
type diabetes
risk factors
transforming growth factor
vascular endothelial growth factor
drug induced
risk assessment
diabetic nephropathy
oxidative stress