A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology.

Patrícia A Gomes Cristian Bodo Carlos J Nogueras-Ortiz Martina K SamiotakiMinghao ChenCarina Soares-Cunha Joana Margarida Silva Bárbara Coimbra George M Stamatakis Liliana SantosGeorge PanayotouFoteini Tzouanou Clarissa L Waites Christos Gatsogiannis Nuno Sousa Dimitrios Kapogiannis Bruno Costa Silva Ioannis Sotiropoulos

Published in: Cell communication and signaling : CCS (2023)

Overall, the spontaneous release method of sEV yield may contribute to the characterization and biomarker profile of physiologically relevant brain-derived sEVs in brain function and pathology. Video Abstract.

Keyphrases

resting state
white matter
cerebral ischemia
multiple sclerosis
blood brain barrier
subarachnoid hemorrhage