Anti-PD-L1 antibodies promote cellular proliferation by activating the PD-L1-AXL signal relay in liver cancer cells.

Toshimitsu TanakaHironori KogaHiroyuki SuzukiHideki IwamotoTakahiko SakaueAtsutaka MasudaToru NakamuraJun AkibaHirohisa YanoTakuji TorimuraTakumi Kawaguchi

Published in: Hepatology international (2023)

Therapeutic anti-PD-L1 antibodies promote cell proliferation by stabilizing the PD-L1-AXL complex in PD-L1-abundant neoplasms, including in HCC with mesenchymal components. Such a mechanism may contribute to the development of hyperprogressive disease.

Keyphrases

cell proliferation
signaling pathway
tyrosine kinase
stem cells
cell cycle
pi k akt