Anti-Th/To Antibodies: Association With Lung Disease and Potential Protection From Systemic Sclerosis-Related Cancer? Comment on the Article by Mecoli et al.

Autoantibodies in systemic sclerosis (SSc) can help stratify patients into more clinically-relevant subsets (reviewed in (1)). We read with interest the study of 804 adult SSc by Mecoli et al. (2), which represents the one of the largest study of anti-Th/To antibodies. The prevalence of 8.3% utilizing immunoprecipitation (IP) of four in-vitro transcribed and translated Th/To components (hPOP1/Rpp25/Rpp30/Rpp40) is consistent with previous studies (reviewed in (3)) (Figure 1).