KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.
Ernest TerribasMarco FernándezHelena MazuelasJuana Fernández-RodríguezJosep BiaynaIgnacio BlancoGabriela BernalIrma Ramos-OliverCraig ThomasRajiv GuhaXiaohu ZhangBernat GelCleofé RomagosaMarc FerrerConxi LázaroEduard SerraPublished in: Neuro-oncology advances (2020)
The mitotic spindle kinesins KIF11 and KIF15 and the cytokinetic kinesin KIF23 play a clear role in maintaining MPNST cell survival and may represent potential therapeutic vulnerabilities. Although further in vivo evidences are still mandatory, we propose a simultaneous suppression of KIF11, KIF15, and BRD4 as a potential therapy for MPNSTs.
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