A Curcumin-Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment.
Hang YaoFeifei WangHui ChongJingjing WangYang BaiMeng DuXiaohui YuanXiaofei YangMing WuYuping LiHuan PangPublished in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Overexpression of classically activated macrophages (M1) subtypes and assessed reactive oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present, the treatment system of these two problems has yet to be established. Here, the chemotherapy drug curcumin (CCM) is decorated with Prussian blue analogs in a straightforward and cost-saving manner. Modified CCM can be released in inflammatory tissue (acidic environment), eventually causing M1 macrophages to transform into M2 macrophages and inhibiting pro-inflammatory factors. Co(III) and Fe(II) have abundant valence variations, and the lower REDOX potential in CCM-CoFe PBA enables ROS clearance through multi-nanomase activity. In addition, CCM-CoFe PBA effectively alleviated the symptoms of UC mice induced by DSS and inhibited the progression of the disease. Therefore, the present material may be used as a new therapeutic agent for UC.
Keyphrases
- reactive oxygen species
- ulcerative colitis
- cell death
- dna damage
- type diabetes
- gold nanoparticles
- oxidative stress
- squamous cell carcinoma
- metabolic syndrome
- ionic liquid
- climate change
- cell proliferation
- quantum dots
- transcription factor
- insulin resistance
- skeletal muscle
- locally advanced
- molecular dynamics simulations
- sleep quality
- high fat diet induced
- wild type