Harnessing ester bond chemistry for protein ligation.

P G YoungY YosaatmadjaP W R HarrisIvanhoe K H LeungE N BakerChristopher J Squire

Published in: Chemical communications (Cambridge, England) (2018)

The hydrolysis potential of ester bonds in covalently cross-linking proteins is captured in our novel protein ligation technology. This new type of "molecular superglue" based on the spontaneously-formed Thr-Gln ester bonds found in cell-surface adhesins, affords a unique mechanism to both rationally assemble and disassemble complex protein nanomaterials.

Keyphrases

cell surface
protein protein
amino acid
binding protein
machine learning
single molecule
artificial intelligence