Xenofree generation of limbal stem cells for ocular surface advanced cell therapy.

Nuria Nieto-NicolauEva M Martínez-ConesaAlba M Velasco-GarcíaCaterina Aloy-RevertéAnna VilarrodonaRicardo-Pedro Casaroli-Marano

Published in: Stem cell research & therapy (2019)

The combination of XSHEM and PLA feeder cells efficiently sustained LSC xenofree cultures for clinical application. Moreover, PLA feeder layers were able to improve the LSC potential characteristics. Our results would have direct clinical application in CLET for advanced therapy.

Keyphrases

cell therapy
stem cells
induced apoptosis
mesenchymal stem cells
cell cycle arrest
oxidative stress
cell death
human health
risk assessment
pi k akt