Antibody responses to de novo identified citrullinated fibrinogen peptides in rheumatoid arthritis and visualization of the corresponding B cells.
Vijay JoshuaLoes SchobersPhilip J TitcombeLena IsraelssonJohan RönnelidMonika HanssonAnca I CatrinaGer J M PruijnVivianne MalmströmPublished in: Arthritis research & therapy (2016)
Our data show that several cit-Fib peptides are targeted by autoantibodies in RA, but not in PsA/AS, implicating that these are not due to arthritis but more specific for RA etiology. The RA-associated anti-cit protein response is broad with many parallel immune responses. The association between cit-Fib autoantibodies and the PTPN22 R620W risk allele supports the hypothesis of altered B cell regulation, such as autoreactive B cells evading tolerance checkpoints.
Keyphrases
- rheumatoid arthritis
- disease activity
- systemic lupus erythematosus
- immune response
- ankylosing spondylitis
- amino acid
- prostate cancer
- interstitial lung disease
- electronic health record
- cancer therapy
- toll like receptor
- binding protein
- inflammatory response
- drug delivery
- machine learning
- artificial intelligence
- systemic sclerosis
- data analysis