Impaired response to sleep deprivation in heterozygous Disc1 mutant mice.

Chih-Yu TsaoLi-Heng TuanLukas Jyuhn-Hsiarn LeeChih-Min LiuHai-Gwo HwuLi-Jen Lee

Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2021)

The present study proposes that sleep disturbance could be pathogenic especially in genetically predisposed subjects who fail to cope with the stress. Potential therapeutic strategies for psychiatric disorders targeting the mRNA translation machinery could be considered.

Keyphrases

sleep quality
physical activity
wild type
high fat diet induced
metabolic syndrome
adipose tissue
drug delivery
depressive symptoms