Preclinical Development of CAR T Cells with Antigen-Inducible IL18 Enforcement to Treat GD2-Positive Solid Cancers.

Lena Fischer-Riepe Sareetha Kailayangiri Katharina Zimmermann Rita Pfeifer Michael Aigner Bianca Altvater Sascha Kretschmann Simon Völkl Jordan Hartley Celine Dreger Katja Petry Andreas Bosio Angelika von Döllen Wolfgang Hartmann Holger N Lode Dennis Görlich Andreas Mackensen Melanie Jungblut Axel Schambach Hinrich Abken Claudia Rossig

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

These results pave the way for clinical investigation of GD2IL18CART in pediatric and adult patients with neuroblastoma and other GD2-positive cancers (EU CT 2022- 501725-21-00). See related commentary by Locatelli and Quintarelli, p. 3361.

Keyphrases

induced apoptosis
cell cycle arrest
computed tomography
image quality
contrast enhanced
magnetic resonance imaging
childhood cancer
positron emission tomography
magnetic resonance
oxidative stress
dual energy
signaling pathway
mesenchymal stem cells
bone marrow