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Deconstructing and reconstructing the mouse and human early embryo.

Marta N ShahbaziMagdalena Zernicka Goetz
Published in: Nature cell biology (2018)
The emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body plan are laid throughout the first days of post-implantation development as embryonic stem cells undergo symmetry breaking and initiate lineage specification, in a process that coincides with a global morphological reorganization of the embryo. Here, we review experimental models and how they have shaped our current understanding of the post-implantation mammalian embryo.
Keyphrases
  • embryonic stem cells
  • pregnancy outcomes
  • endothelial cells
  • transcription factor
  • single cell
  • induced pluripotent stem cells
  • pregnant women