Positive Anti-SSA/Ro Antibody in a Woman with SARS-CoV-2 Infection Using Immunophenotyping: A Case Report.
Po-I HuangTing-Chun LinFeng-Cheng LiuYi-Jung HoJeng-Wei LuTe-Yu LinPublished in: Medicina (Kaunas, Lithuania) (2020)
The clinical spectrum of novel coronavirus infection appears to be wide, encompassing asymptomatic infection, mild upper respiratory tract illness, and severe viral pneumonia, with respiratory failure and even death. Autoantibodies, especially antiphospholipid antibodies, can occur in severe infections. Other autoantibodies are seldom reported. Here, a 60-year-old female patient without dry-mouth symptoms detected positive for anti-60 kDa SSA/Ro antibodies on day 43 after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To investigate this unique clinical case of SARS-CoV-2 infection, immunological characteristics of this case were detected by using flow cytometry and were compared to the other three groups of patients-health subjects, 2019 novel coronavirus disease (COVID-19) recovery patients, and Sjögren's syndrome (SS) patients. Monitoring the autoantibody level and the development of subsequently related autoimmune diseases are warranted after SARS-CoV-2 infection.
Keyphrases
- respiratory syndrome coronavirus
- coronavirus disease
- end stage renal disease
- sars cov
- ejection fraction
- chronic kidney disease
- newly diagnosed
- flow cytometry
- systemic lupus erythematosus
- prognostic factors
- healthcare
- respiratory tract
- public health
- respiratory failure
- risk assessment
- social media
- intensive care unit
- acute respiratory distress syndrome
- drug induced