Comparison of three different methods to detect bone marrow involvement in patients with neuroblastoma.
Felix SchriegelSabine Taschner-MandlMarie BernkopfUwe GrunwaldNikolai SiebertPeter F AmbrosInge AmbrosHolger N LodeGuenter HenzeKaroline EhlertPublished in: Journal of cancer research and clinical oncology (2021)
The combination of AIPF/FCM yielded the highest detection rate of NB cells in BM. AIPF was the single, most sensitive method in detecting these cells. Although CM did not provide any additional positive results, it is still a useful, readily available and cost-effective tool. The prognostic significance of FCM and AIPF should be confirmed in a prospective study with a larger number of patients.
Keyphrases
- induced apoptosis
- bone marrow
- cell cycle arrest
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- mesenchymal stem cells
- endoplasmic reticulum stress
- oxidative stress
- signaling pathway
- cell proliferation
- real time pcr
- pi k akt
- patient reported outcomes
- sensitive detection
- loop mediated isothermal amplification
- quantum dots