New T-cell therapies for brain metastasis, CD133 in the driver's seat.

Anthony R Sloan Mihika Thapliyal Justin D Lathia

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Chimeric antigen receptor (CAR)-T cell immunotherapy has revolutionized cancer therapy for some advanced cancers, but success is predicated on identifying the correct cell surface target. In a recent article, the authors leveraged the cancer stem cell surface antigen, CD133, to develop a CAR-T therapy for brain metastasis.

Keyphrases

cell surface
papillary thyroid
resting state
squamous cell
childhood cancer
functional connectivity
nk cells
young adults