A Corticocortical Circuit Directly Links Retrosplenial Cortex to M2 in the Mouse.
Naoki YamawakiJelena RudulovicGordon M G ShepherdPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2017)
Corticocortical pathways interconnect cortical areas extensively, but the cellular connectivity in these pathways remains largely uncharacterized. Here, we show that a posterior part of secondary motor cortex receives corticocortical axons from the rostral retrosplenial cortex (RSC) and these form monosynaptic excitatory connections onto a wide spectrum of excitatory projection neurons in this area. Our results define a cellular basis for direct communication from RSC to this medial frontal area, suggesting a direct link from dorsal hippocampal networks involved in spatial cognition and navigation (the "map") to sensorimotor networks involved the control of movement (the "motor").