Amelioration of Neurochemical Alteration and Memory and Depressive Behavior in Sepsis by Allopurinol, a Tryptophan 2,3-Dioxygenase Inhibitor.
Kiuanne Lino Lobo MetzkerKhiany MathiasRichard Simon MachadoSandra BonfanteLarissa JoaquimMarina Goulart da SilvaGuilherme Cabreira DarosElisa Mitkus Flores LinsFernanda BelleCarolina Giassi AlanoRafaela Tezza MatiolaIsabela da Silva LemosLucinéia Gainski DanielskiFernanda Frederico GavaRafael Mariano de BitencourtFranciane BobinskiEmilio Luiz StreckGislaine Zilli ReusFabricia PetronilhoPublished in: CNS & neurological disorders drug targets (2024)
In summary, TDO inhibition effectively prevented depressive behavior and memory impairment 10 days after CLP by reducing acute BBB permeability, neuroinflammation, oxidative stress, and mitochondrial alteration.
Keyphrases
- oxidative stress
- bipolar disorder
- working memory
- liver failure
- stress induced
- blood brain barrier
- acute kidney injury
- intensive care unit
- dna damage
- traumatic brain injury
- respiratory failure
- lipopolysaccharide induced
- diabetic rats
- endothelial cells
- lps induced
- aortic dissection
- septic shock
- cognitive impairment
- cerebral ischemia
- hepatitis b virus
- brain injury