Identifying genetic differences between bipolar disorder and major depression through multiple GWAS.
Georgia PanagiotaropoulouKajsa-Lotta Georgii HellbergJonathan R I ColemanDarsol SeokJanos L Kalmannull nullnull nullnull nullPhilip B MitchellPeter R SchofieldAndreas J ForstnerMichael BauerLaura J ScottCarlos N PatoMichele T PatoQingqin S LiGeorge KirovMikael LandénLina JonssonBertram Müller-MyhsokJordan W SmollerElisabeth B BinderTanja M BrücklDarina CzamaraSandra Van der AuweraHans J GrabeGeorg HomuthCarsten O SchmidtJames B PotashRaymond J DePauloFernando S GoesDean F MacKinnonFrancis M MondimoreMyrna M WeissmanJianxin ShiMark A FryeJoanna M BiernackaAndreas ReifStephanie H WittRené R KahnMarco M BoksMichael J OwenKatherine Gordon-SmithBrittany L MitchellNicholas G MartinSarah E MedlandLisa JonesJames A KnowlesDouglas F LevinsonMichael C O'DonovanCathryn M LewisGerome D BreenThomas M WergeAndrew J SchorkRoel A OphoffStephan RipkeLoes M Olde LoohuisPublished in: medRxiv : the preprint server for health sciences (2024)
We find that MDD and BD, including BD with a depressive onset, are genetically distinct. Further, our findings support the hypothesis that Controls - MDD - BD primarily lie on a continuum of genetic risk. Future studies with larger and richer samples will likely yield a better understanding of these findings and enable the development of better genetic predictors distinguishing BD and, importantly, BD with depressive onset from MDD.