Inhalational exposure history is associated with differential sinonasal gene expression profiles and clinical outcomes in chronic rhinosinusitis patients: A pilot study.

Cameron P WordenBrian D ThorpCharles S EbertCristine N Klatt-CromwellBrent A SeniorAdam J KimpleMeghan E RebuliIlona Jaspers

Published in: International forum of allergy & rhinology (2024)

Inhalational exposure (IE) history assessment is important and may guide chronic rhinosinusitis disease management. Combined exposure status was the most significant factor across differential gene expression analyse IE history was associated with pro-inflammatory transcriptome changes and worse clinical outcomes.

Keyphrases

chronic rhinosinusitis
gene expression
end stage renal disease
genome wide
newly diagnosed
dna methylation
peritoneal dialysis
prognostic factors
single cell
rna seq
patient reported