Prenatal exposure to pregabalin, birth outcomes and neurodevelopment - a population-based cohort study in four Nordic countries.
Elena DudukinaSzimonetta Komjáthiné SzépligetiPär KarlssonKofi AsomaningAnne Kjersti DaltveitKatja HakkarainenFabian HotiHelle KielerAstrid LundeIngvild OdsbuMatti RantanenJohan ReutforsLaura SaarelainenVera EhrensteinGunnar ToftPublished in: Drug safety (2023)
Prenatal exposure to pregabalin was not associated with low birth weight, preterm birth, small for gestational age, low Apgar score, microcephaly, autism spectrum disorders, or intellectual disability. On the basis of the upper value of the 95% confidence interval, increased risks greater than 1.8 were unlikely for any major congenital malformation and ADHD. For stillbirth and most groups of specific major congenital malformations, the estimates attenuated in MH meta-analysis.
Keyphrases
- preterm birth
- intellectual disability
- gestational age
- autism spectrum disorder
- low birth weight
- birth weight
- attention deficit hyperactivity disorder
- human milk
- systematic review
- neuropathic pain
- pregnant women
- postoperative pain
- meta analyses
- human health
- spinal cord
- zika virus
- metabolic syndrome
- preterm infants
- working memory
- adipose tissue
- type diabetes
- insulin resistance
- body mass index
- climate change