The extracellular HDAC6 ZnF UBP domain modulates the actin network and post-translational modifications of Tau.
Abhishek Ankur BalmikShweta Kishor SonawaneSubashchandrabose ChinnathambiPublished in: Cell communication and signaling : CCS (2021)
HDAC6 ZnF UBP was found to be involved in cytoskeletal re-organization by modulating actin dynamics and tubulin localization. Overall, our study suggests that ZnF domain of HDAC6 performs various regulatory functions apart from its classical function in aggresome formation in protein misfolding diseases. Video abstract.