Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions with Efavirenz Involving Simultaneous Inducing and Inhibitory Effects on Cytochromes.

Catia MarzoliniRajith RajoliManuel BattegayLuigia ElziDavid BackMarco Siccardi

Published in: Clinical pharmacokinetics (2017)

PBPK modeling constitutes a useful mechanistic approach for the quantitative prediction of DDI involving simultaneous inducing or inhibitory effects on multiple CYPs as often encountered with antiretroviral drugs.

Keyphrases

hiv infected
hiv infected patients
antiretroviral therapy
human immunodeficiency virus
hiv aids
hiv positive
high resolution
drug induced
emergency department
adverse drug
hepatitis c virus
south africa
electronic health record