Let-7c restores radiosensitivity and chemosensitivity and impairs stemness in oral cancer cells through inhibiting interleukin-8.

Chih-Yu PengTung-Yuan WangShiuan-Shinn LeePei-Ling HsiehYi-Wen LiaoLo-Lin TsaiChih-Yuan FangCheng-Chia YuChing-Shui Hsieh

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2018)

These findings revealed the significance of let-7c in the contribution of oral cancer stemness and radio/chemoresistance. Targeting let-7c and its downstream IL-8 may be beneficial to prevent cancer recurrence and metastasis of oral squamous cell carcinoma.

Keyphrases

stem cells
epithelial mesenchymal transition
cancer stem cells
papillary thyroid
signaling pathway
squamous cell
cancer therapy
single cell
childhood cancer