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Derivation and characterization of an HIV-1 mutant that rescues IP6 binding deficiency.

Daniel PostonTrinity ZangPaul D Bieniasz
Published in: Retrovirology (2021)
Overall these results suggest that IP6-Gag and Gag-Gag contacts are finely tuned to generate a Gag lattice of optimal stability, and that under certain conditions BVM can rescue IP6 deficiency. Additionally, our work identifies an inducible virion assembly system that can be utilized to visualize HIV-1 assembly events using live cell microscopy.
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