Insights into the Crystallization and Structural Evolution of Glycine Dihydrate by In Situ Solid-State NMR Spectroscopy.
Paolo Cerreia VioglioGiulia MollicaMarie JuramyColan E HughesP Andrew WilliamsFabio ZiarelliStéphane VielPierre ThureauKenneth D M HarrisPublished in: Angewandte Chemie (International ed. in English) (2018)
In situ solid-state NMR spectroscopy is exploited to monitor the structural evolution of a glycine/water glass phase formed on flash cooling an aqueous solution of glycine, with a range of modern solid-state NMR methods applied to elucidate structural properties of the solid phases present. The glycine/water glass is shown to crystallize into an intermediate phase, which then transforms to the β polymorph of glycine. Our in situ NMR results fully corroborate the identity of the intermediate crystalline phase as glycine dihydrate, which was first proposed only very recently.