Intratympanic Lipopolysaccharide Elevates Systemic Fluorescent Gentamicin Uptake in the Cochlea.

Yongchuan ChaiWeiwei HeWeiqiang YangAlisa P HetrickJessica G GonzalezLiana SargsyanHao WuTimothy T K JungHongzhe Li

Published in: The Laryngoscope (2021)

In summary, this study suggests that the pathological cochlea is more susceptible to ototoxic drugs, including aminoglycosides, and justified the clinical concern of aminoglycoside ototoxicity in the AOM treatment. Laryngoscope, 131:E2573-E2582, 2021.

Keyphrases

inflammatory response
pseudomonas aeruginosa
toll like receptor
quantum dots
living cells
combination therapy
drug induced
label free
multidrug resistant
fluorescent probe