So Grateful for My X: Sex Chromosomes Drive Differences in Glioblastoma Immunity.

Males are at a greater risk of developing glioblastoma and face poorer prognoses compared with their female counterparts for reasons that are not well understood. Lee and colleagues uncover a role for sex-based differences in CD8+ T-cell function, which adds another layer to our growing understanding that antitumor immunity is not generated equivalently between males and females. See related article by Lee et al., p. 2090 (5).