A Targeted Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Quantification of Peptides from the Carboxyl-terminal Region of Type III Procollagen, Biomarkers of Collagen Turnover.
Huu Hien HuynhKatrina ForrestJessica O BeckerMichelle A EmrickGeoffrey D MillerDanielle MoncrieffeDavid A CowanAndreas ThomasMario ThevisMichael J MacCossBen HoffstromPeter H ByersDaniel EichnerAndrew N HoofnaglePublished in: Clinical chemistry (2022)
Our method quantifies the proteins belonging to the family of P-III-CP and type III collagen degradation products in human serum, which could be used to detect GH administration in athletes and better understand diseases involving GH therapy or altered type III collagen turnover.