Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis.

Andrés Cruz-HerranzMichael DietrichAlexander M HillaHao H YiuMarc H LevinChristina HeckerAndrea IssbernerAngelika HallenbergerChristian CordanoKlaus Lehmann-HornLisanne J BalkOrhan AktasJens IngwersenCharlotte von GallHans-Peter HartungScott S ZamvilDietmar FischerPhilipp AlbrechtAri J Green

Published in: Journal of neuroinflammation (2019)

Retinal neuroaxonal damage develops quickly during EAE. Changes in retinal thickness mirror neuronal loss and clinical severity. Monitoring of the IRL thickness after immunization against MOG35-55 in C57Bl/6J mice seems the most convenient model to study retinal neurodegeneration in EAE.

Keyphrases

optical coherence tomography
diabetic retinopathy
optic nerve
metabolic syndrome
high fat diet induced
skeletal muscle
insulin resistance
wild type