Sex-by-formulation interaction in bioequivalence trials with transdermal patches.
Esperanza González-RojanoJulio MarcoteguiSusana Morales-AlcelayCovadonga ÁlvarezJohn GordonFrancisco Abad-SantosAlfredo García-ArietaPublished in: European journal of clinical pharmacology (2019)
The sex-by-formulation interaction detected in some pharmacokinetic parameters of some studies is excluded when the study is repeated, which shows that these results are not reproducible. There is no evidence to require bioequivalence demonstration for transdermal patches in males and females separately.
Keyphrases