Investigation of screening method for DNMT3A mutations by high-resolution melting analysis in acute myeloid leukemia.

Shumpei MizutaNoriko YamaneTakao KomaiYusuke KobaTakahito KawataNaoya UkyoAkira TamekaneMitsumasa Watanabe

Published in: International journal of laboratory hematology (2019)

High-resolution melting analysis has sufficient performance for the detection of DNMT3A mutations in AML. This approach can facilitate rapid AML genotyping at diagnosis in clinical settings.

Keyphrases

high resolution
dna methylation
acute myeloid leukemia
mass spectrometry
genome wide
high throughput
gene expression
allogeneic hematopoietic stem cell transplantation
single cell
quantum dots
real time pcr
genetic diversity