CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletion.
Theodoros-Ioannis PapadimitriouPrashant SinghArjan van CaamBirgitte WalgreenMark A J GorrisElly L VittersIris L van IngenMarije I KoendersRuben L SmeetsMadelon C VonkJolanda M de VriesPeter M van der KraanYpke van OosterhoutMartijn A HuynenHans J P M KoenenRogier M ThurlingsPublished in: Annals of the rheumatic diseases (2023)
Together, the findings imply costimulatory molecules as key regulators of cytotoxicity-driven pathology in systemic autoimmune disease, yielding CD7 as a novel target for selective depletion of pathogenic cells.