Expanding the Pillararene Chemistry: Synthesis and Application of a 10 + 1 Functionalized Pillar[5]arene.
Márton BojtárAndrás SimonPetra BombiczIstván BitterPublished in: Organic letters (2017)
A novel functionality was introduced in the pillararene family by the Claisen rearrangement of monoallyl pillar[5]arene. This new key derivative can lead to the formation of a 10 + 1 functionalized derivative, a useful scaffold for further derivatization. Except for the previously known monodeprotection reaction, all steps proceed efficiently with high yields and easy separation. In addition, a solvent-responsive pseudo[1]rotaxane was synthesized based on this novel functionality.
Keyphrases
- water soluble
- quantum dots
- liquid chromatography
- molecularly imprinted
- ms ms
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- simultaneous determination
- cancer therapy
- gas chromatography mass spectrometry
- ionic liquid
- solid phase extraction
- tandem mass spectrometry
- mass spectrometry
- gas chromatography
- high resolution mass spectrometry
- drug discovery
- drug delivery