Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis.
Hagit Baris FeldmanChofit Chai GadotDavid ZahlerAdi MoryGalit AviramEmil ElhananGabi SheferIlana GoldinerYam AmirAlina KurolapJacob N AblinPublished in: The New England journal of medicine (2023)
Two siblings presented with cardiomyopathy, hypertension, arrhythmia, and fibrosis of the left atrium. Each had a homozygous null variant in CORIN , the gene encoding atrial natriuretic peptide (ANP)-converting enzyme. A plasma sample obtained from one of the siblings had no detectable levels of corin or N-terminal pro-ANP but had elevated levels of B-type natriuretic peptide (BNP) and one of the two protein markers of fibrosis that we tested. These and other findings support the hypothesis that BNP cannot fully compensate for a lack of activation of the ANP pathway and that corin is critical to normal ANP activity, left atrial function, and cardiovascular homeostasis.
Keyphrases
- left atrial
- catheter ablation
- atrial fibrillation
- mitral valve
- blood pressure
- left ventricular
- heart failure
- left atrial appendage
- intellectual disability
- copy number
- liver fibrosis
- genome wide
- pulmonary artery
- dna methylation
- pulmonary embolism
- amino acid
- anti inflammatory
- inferior vena cava
- arterial hypertension
- vena cava
- pulmonary arterial hypertension