Invariant BECN1 CXXC motifs bind Zn 2+ and regulate structure and function of the BECN1 intrinsically disordered region.

Shreya MukhopadhyaySubeksha SubediJesse B HopkinsAngel UgrinovSrinivas ChakravarthyChristopher L ColbertSangita C Sinha

Published in: Autophagy (2023)

: radius of gyration; SASBDB: small angle scattering biological data bank; SEC: size-exclusion chromatography; SEC-SAXS: size-exclusion chromatography in tandem with small angle X-ray scattering; TEV: tobacco-etch virus; TFE: 2,2,2-trifluoroethanol; TPEN: N,N,N,N-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine; Vc: volume of correlation; WT: wild-type.

Keyphrases

high resolution
wild type
mass spectrometry
high speed
tandem mass spectrometry
liquid chromatography
high performance liquid chromatography
electronic health record
heavy metals
magnetic resonance imaging
monte carlo
machine learning
dual energy